ยุ่งกันใหญ่ งวงตาล สงสัยว่า ลดความดัน ลดน้ำตาลในเลือด

 

ก่อนหน้า เคยรู้มาว่า งวงตาล  มีสารลดความดันโลหิต    ต่อมาเพิ่งรู้ว่า ลดน้ำตาลในเลือด แต่สกัดจากเหล้า  ไม่รู้ต้มน้ำ จะใช้ได้มั้ย  แปลกดี

ลองสืบจาก น้อง กุ๊ก

 

 New spirostane-type steroid saponins with antidiabetogenic activity from   Borassus flabellifer.

M Yoshikawa, F Xu, T Morikawa, Y Pongpiriyadacha, S Nakamura, Y Asao, A Kumahara, H Matsuda

Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan. [email protected]

 

abstract

The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A-F (1-6), were isolated together with 23 known constituents. The structures of borassosides (1-6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.

 

โปรดทราบ งวงตาล  มีบริษัท หัวหมอ ทำเป็นเม็ดขาย  ผสมอย่างอื่นอีกเล็กน้อย ขายเม็ดละ 7 บาท น่าจะหา แนวทางกินแบบภูมิปัญญา

ใบกำแพงเจ็ดชั้น

Absolute structures of new megastigmane glycosides, foliasalaciosides E(1), E(2), E(3), F, G, H, and I from the leaves of Salacia chinensis.

Y Zhang, S Nakamura, Y Pongpiriyadacha, H Matsuda, M Yoshikawa

Kyoto Pharmaceutical University, Kyoto, Japan.

Chemical & pharmaceutical bulletin 2008 Apr

abstract

Following the investigation of foliasalaciosides A(1), A(2), B(1), B(2), C, and D, seven new megastigmane glycosides named foliasalaciosides E(1)-I (1-7), together with four known constituents, were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The absolute stereostructures of the new compounds were characterized on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method.

กำแพงเจ็ดชั้น

Title;Biological Activities of Salacia chinensis Originating in Thailand: The Quality Evaluation Guided by .ALPHA.-Glucosidase Inhibitory Activity

Author;YOSHIKAWA MASAYUKI(Kyoto Pharmaceutical Univ., JPN)   PONGPIRIYADACHA Y(Kyoto Pharmaceutical Univ., JPN)   KISHI AKINOBU(Kyoto Pharmaceutical Univ., JPN)   KAGEURA TADASHI(Kyoto Pharmaceutical Univ., JPN)   WANG T(Kyoto Pharmaceutical Univ., JPN)   MORIKAWA TOSHIO(Kyoto Pharmaceutical Univ., JPN)   MATSUDA HISASHI(Kyoto Pharmaceutical Univ., JPN)   

Journal Title;Journal of the Pharmaceutical Society of Japan

ISSN:0031-6903

VOL.123;NO.10;PAGE.871-880(2003)

Figure&Table&Reference;FIG.1, TBL.6, REF.29

Pub. Country;Japan

Language;Japanese

Abstract;In the course of our characterization studies on anti-obese and antidiabetogenic principles in medicinal foodstuffs, we found that the methanolic extract from the stems of Salacia chinensis (Hippocerateaceae) showed potent anti-hyperglycemic effects in oral sucrose or maltose-loaded rats, inhibitory effects on intestinal .ALPHA.-glucosidase, rat lens aldose reductase, formation of Amadori compounds and advanced glycation end-products, nitric oxide production from lipopolysaccharide-activated mouse peritoneal macrophage, and radical scavenging activities. Those in vivo and in vitro biological activities were compared with those of S. oblonga and S. reticulata. In addition, we isolated the principal .ALPHA.-glucosidase inhibitor, salacinol, from the stems of S. chinensis and examined .ALPHA.-glucosidase inhibitory activities of eleven samples of S. chinensis collected in Thailand. (author abst.)

Biological activities of Salacia chinensis originating in Thailand: The quality evaluation guided by α-glucosidase inhibitory activity

Auteur(s) / Author(s)

YOSHIKAWA Masayuki ; PONGPIRIYADACHA Yutana ; KISHI Akinobu ; KAGEURA Tadashi ; TAO WANG ; MORIKAWA Toshio ; MATSUDA Hisashi ;

Résumé / Abstract

In the course of our characterization studies on anti-obese and antidiabetogenic principles in medicinal foodstuffs, we found that the methanolic extract from the stems of Salacia chinensis (Hippocerateaceae) showed potent anti-hyperglycemic effects in oral sucrose or maltose-loaded rats, inhibitory effects on intestinal α-glucosidase, rat lens aldose reductase, formation of Amadori compounds and advanced glycation end-products, nitric oxide production from lipopolysaccharide-activated mouse peritoneal macrophage, and radical scavenging activities. Those in vivo and in vitro biological activities were compared with those of S. oblonga and S. reticulata. In addition, we isolated the principal α-glucosidase inhibitor, salacinol, from the stems of S. chinensis and examined α-glucosidase inhibitory activities of eleven samples of S. chinensis collected in Thailand.

Revue / Journal Title

Yakugaku zasshi   ISSN 0031-6903 

Source / Source

2003, vol. 123, n^o10, pp. 871-880 [10 page(s) (article)]

Mai TT, Thu NN, Tien PG, Van Chuyen N 
Alpha-glucosidase inhibitory and antioxidant activities of Vietnamese edible plants and their relationships with polyphenol contents. [Journal Article]
J Nutr Sci Vitaminol (Tokyo) 2007 Jun; 53(3):267-76.

The prevention and treatment of non-communicable diseases by using the beneficial biological effects of polyphenolic plants have attracted increasing interest from nutritional scientists. The a-glucosidase inhibitory and antioxidant activities of aqueous and methanolic extracts from 28 common Vietnamese edible plants, comprising 4 groups (plants used for making drinks, edible wild vegetables, herbs, and dark green vegetables), were investigated in vitro. The polyphenol contents of these extracts were determined by the Folin-Ciocalteu method and calculated as catechin equivalents. The extracts from plants used for making drinks showed the highest activities for both a-glucosidase inhibition and as antioxidants, followed by edible wild vegetables, herbs, and dark green vegetables. Positive relationships among alpha-glucosidase inhibitory activities, antioxidant activities and polyphenol contents of these 28 edible plants were found in both aqueous and methanolic extracts.

Four new promising materials that are similar to or better than guava leaf extract, including

Syzygium zeylanicum,

Cleistocalyx operculatus,

Horsfieldia amygdalina and

Careya arborea

demonstrated high alpha-glucosidase inhibitory activity (93, 76, 68 and 67%, respectively) at the final concentration of 0.8 mg lyophilized material/mL solution

and antioxidant activity (85, 87, 78 and 80%, respectively) at the final concentration of 30 pg lyophilized material/mL solution.

These four edible plants contained significantly high polyphenol contents (equivalent to 251.7, 146.6, 136.6 and 168.6 mg of catechin/g dry weight, respectively).

Thus, these four materials might be possible new sources of a-glucosidase inhibition and antioxidants suitable for use as functional foods in the future.

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[ฺBuffalow Wolaffub]

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