กะเม็ง ยาบำรุง และรักษาโรคร้าย เป็นวัชพืชในนา หน้าบ้าน
กะเม็ง เป็นพืชล้มลุก เป็นวัชพืช ในนาบ้าง ตามดินทั่วไปบ้าง
หากพูดถึง "กะเม็ง" ถือเป็นพืชที่มีค่ามหาศาล
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ส่วนแพทย์หลวงไทย สมัย ร ๓ ร๔ กรมหลวงวงษาธิราชสนิท อดีตอธิบดี กรมแพทย์ เขียนตำราสรรพคุณยา ที่มีบันทึกไว้ว่า
กะเม็ง ต้น นั้นรู้แก้ลมให้กระจาย แก้โลหิตอันกระทำให้ร้อน
ดอก แก้ดีอันฟุ้งซ่านให้บริบูรณ์ ลูกรู้แก้ลมให้กระจาย
ราก นั้นรู้แก้ลมอันวิงเวียน อยู่ในอุทรให้ขึ้นเบื้องบน
http://arcbs.bsru.ac.th/local/spthai/1gameng.pdf จาก ม ราชภัฎ สมเด็จเจ้าพระยา
http://www.vcharkarn.com/include/vcafe/showkratoo.php?Pid=50625
http://cyberlab.lh1.ku.ac.th/elearn/faculty/fisher/fi15/web/Eclipta%20prostrata%20(%20false%20daisy%20).htm จาก ม เกษตร กำแพงแสน
ดูรูป link ข้างล่าง
ข้อมูลเด็ด อยู่ข้างล่างนี้ การต้านมะเร็งตับ ในระดับหลอดทดลอง โดยนักวิชาการ สถาบันวิจัยจุฬาภรณ์ และ มหิดล
http://www.scisoc.or.th/stt/32/sec_b/paper/stt32_B5_B0083.pdf
จากผู้เรียนรู้รุ่นหลัง
ทานครั้งละ 9-15 กรัม ตามตำรายาจีน
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Medicinal Uses of Ecliptae Herba:
Antiseptic; Astringent; Depurative; Emetic; Febrifuge; Ophthalmic; Purgative; Styptic; Tonic.
This species is widely used in traditional Chinese herbal medicine, and in Ayurveda. It is considered to be the best remedy for the hair and is also used as a rejuvenative and liver tonic.
The whole plant is astringent, deobstruent, depurative, emetic, febrifuge, ophthalmic, purgative, styptic and tonic. It is used internally in the treatment of dropsy and liver complaints, anaemia, diphtheria etc, tinnitus, tooth loss and premature greying of the hair. Externally, it is used as an oil to treat hair loss and is also applied to athlete's foot, eczema, dermatitis, wounds etc.
The plant juice, mixed with an aromatic (essential oil), is used in the treatment of catarrhal problems and jaundice.
The leaves are used in the treatment of scorpion stings.
The plant is harvested as it comes into flower and is dried for later use.
The roots are emetic and purgative. They are applied externally as an antiseptic to ulcers and wounds, especially in cattle.
Dye. A black dye is obtained from the plant. It is used as a hair dye and for tattooing.
Major use of Ecliptae Herba:
Anti-inflammatory: Used in hepatotoxicity, abortion and miscarriage, uterine hemorrhage, piles, insect bites, stings, swellings and other skin diseases.
Purgative, emetic, cholagogue: Dried aerial parts are used as purgative, emetic, cholagogue in Arabic Countries (Schmucker, 1969); against snakebites in China, for diarrhea in India, for asthma in Thailand.
Snakebites: Fresh aerial part are used to treat snakebites in Brazil (Martz, 1992), for headaches, it is ground in sesame oil and applied to the forehead in India (Nagaraju & Rao, 1990), for common cold in Panama (Solจชs et al., 1995)
Tuberculosis and as haemostatic: Entire plant is used for tuberculosis and as haemostatic in China (Duke & Ayensu, 1985), for inflammation taken with black pepper and raw sugar in India (Jain et al., 1994), to treat wounds (caused by walking barefooted during rain) in Nepal (Manandhar, 1993), to treat vesicles on the skin, plant is crushed and soaked for an hour in water. Extract is applied to affected area in Somalia, to treat leprosy, plant is crushed and mixed with oil, mixture is applied to skin (Samuelsson et al., 1992) and to treat Diabetes mellitus in Taiwan (Lin, 1992).
Treat epilepsy: Leaves are used to treat epilepsy in India, leaves are pounded with garlic and pepper if the patient is unconscious the extract is dropped into the nostril (Reddy et al., 1989), to treat stomach cancer mixed with Ageratum conyzoides, Spilanthes acmella, Vernonia conyzoides and jat, taken after meals in morning and evening in Indonesia (Hsu, 1967) and as an antiasthmatic, in colds, coughs, elephantiasis, hepatitis, splenitis, vertigo in Peru (Duke, 1994).
Insanity: Roots are used for insanity, four to five pills made from the root paste are given twice a day for seven days in India (Jain et al., 1994), for women after childbirth in Malaysia (Burkill, 1966), for jaundice, root plus seed of Ricinus communis are ground and paste is applied to eyes in India (Hemadri & Rao, 1984). 
Traditional Functions and Notes of Ecliptae Herba:
1. Supplement Liver/Kidney Yin
2. Cool Blood Staunch Bleeding
Action: To replenish the liver and the kidney, and to arrest bleeding by removing heat from blood.
Indications: Looseness of teeth, premature greying of hair and beard; dizziness, tinnitus, aching and weakness of the loins and knees; spitting of blood, epistaxis, hematuria and diarrhea with bloody stools due to heat in the blood; abnorml uterine bleeding, traumatic bleeding.
Pharmacological studies:Ecliptae Herba
AntivenOn effect:
The ether extract of the dried aerial parts showed antivenOn effect, when administered 0.5 mg I.P. in mouse. The methanol extract (80%) of the dried aerial parts shows antihepatotoxic activity, administered in rat (1 mg/ml) (Kim & Park, 1994). The hydroalcoholic extract of the dried leaf reported analgesic activity, when administered intragastrically in mouse (100.0 mg/kg). The chloroform and methanol extract of the dried leaf (1.0 gm/ml) showed antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus (Naovi et al., 1991; Phadke and Kulkarni, 1989; Farouk et al., 1983)
Various biological activities have been reported in the literature for extracts of E. prostrata: SNC (Debelmas et al., 1976); hepatoprotective (Chandra et al., 1987; Singh et al., 1993; Sharma et al., 1991; Saxena et al., 1993); antiviral (Kusumoto et al., 1995; Jayaram et al., 1997; Zheng et al., 1988); antirheumatic (Dabral and Sharma, 1983); molluscicidal (Mendes et al., 1984); antimalarial (Misra et al., 1991) and antifertility (Misra et al., 1979).
Effect on Proteolytic and Hemorrhagic activities:
The partially purified ethyl acetate extract (PEE) of Eclipta prostrata L. was found to c ontain 47% of wedelolactone as its major constituent. PEE and wedelolactone demonstrated strong antiproteolytic and antihemorrhagic activity agianst Malayan Pit Viper venom (MPV) in a dose d ependent manner. The extract, at 5 mg/mL, could inhibit proteolytic activity of 100 ug of the venom and hemorrhagic activity of 3 minimum hemorrhagic doses (MHD) to 95% and 65% respectively. At the same concentration, wedelolactone could neutralize the proteolytic activity at around 76% and, at doses of 0.25-1.0mg/mL, offered protection against hemorrhagic activity of the venom in the range 3-3.5%. Both PEE and wedelolactone displayed partial antiphospholipase A2 activity (21% for PEE and 7% for wedelolactone ) and could not neutralize the lethal effect of either 2LD50 0r 4 LD 50 of MPV venom (Pithayanukul, et al 2007).
Clinical trials:
A clinical trial was conducted on 50 children suffering from hepatitis. All patients were administered Eclipta alba powder with honey in doses of 50 mg/kg body wt. in three divided doses for a period of 1-5 weeks. The results revealed that 80 % of patients recovered fully. In another clinical trial 100 % cure in patients of infective hepatitis was observed with Eclipta alba powder (Ministry of Health and Family Welfare Government of India, 2001).
A clinical trial was conduced on 30 patients of viral hepatitis with a compound herbal preparation containing Eclipta alba as one of the ingredients. The response was excellent in terms of clinical as well as biochemical parameters as compared to the placebo group (Ministry of Health and Family Welfare Government of India, 2001).
Quality control including chromatographic fingerprint profiling:Chromatographic profile
The plant material (325 g of leaves) was extracted by maceration with agitation, in methanol (2.0 L) by 24 hours. The solvent was removed with reduced pressure obtaining 70,4 g of residue. It was suspended in 600 ml of water and warmed in water bath at <75 Deg C for 30 min. Then, the aqueous phase was filtered and extracted with ethyl acetate (250 ml x 4), the fractions were dried giving 1,74 g of residue (Wagner et al., 1986).
A thin layer chromatography of ethyl acetate fraction, on silica gel 60 F254, using as eluent chloroform-methanol (70:30) and sprayed with FeCl3/HCl 0,5 N, revealing a spot of green color (Wagner et al., 1986). The EtOAc fraction was separated on medium pressure column chromatography on silica gel 0,015 - 0,040 mm, using as mobile phase CHCl3-MeOH (90:10); (80:20) and (70:30), obtaining two compounds (Eca-1 and Eca-2). Compound Eca-1 was identified like wedelolactone (Zafar et al., 1999) based on its spectroscopic properties. This compound shows on TLC, a blue fluorescence under UV light, a green color is revealed with ferric chloride and a Rf: 0.64, in the solvent system chloroform-methanol (8:2). The compound Eca-2 was identified as a mixture of triterpenes. norwedelactona (Sagar et al., 2000) was detected in the sample under study in very low concentrations detectable only by NMR (Olmedo et al., 2004).
Suggestions and Administrations:
Dosages:Juice, powder
3 ~ 6 ml of the drug in juice form
12 ~ 36 g of the drug in powder form for decoction
Safety data:
The 50% ethanolic extract of the whole plant, administered intraperitoneally in mice, showed a maximum tolerated dose of 1 g/kg (Khin et al., 1978). Hidroalcoholic extract (1: 1) of the dried aerial parts, administered orally at dose of 100 mg/kg, did not show inhibition of implantation and embryotoxic effect in rats female (Mishra et al., 1979). The 95% ethanolic extract of the dried aerial parts, administered orally, intragastrically and intraperitoneally in mice did not present general toxic effect to 2 g/kg dose (Sharma et al., 1991 ; Zhang, 1990).
Contraindications:
The American Herbal Products Association established that it can be safely consumed but it does not have to be taken by patients with acute or chronic diarrhea, or patients who have disorders of spleen (McGuffin et al., 1997).Its effects on lactating children is not documented, and thus it is not recommended to be used during breast-feeding. 
Scientific References:
1.Botanical info and medicinal uses of Ecliptae Herba...
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