ยาต้านเอดส์ จากสมุนไพรไทย จากหมอสมุนไพรไทย สู่หลอดทดลอง ยังรอแพทย์วิจัย
นักวิจัย สมุนไพร จาก มหาวิทยาลัย สงขลานครินทร์ เผยแพร่ รู้กันทั่วโลก แต่คนไทยยังไม่รู้ เกี่ยกับ สมุนไพร ต้านเอดส์
หัวข้าวเย็น และ กระชาย ดังบทคัดย่อ ภาษาอังกฤษ
Anti-HIV-1 protease- and HIV-1 integrase activities of Thai medicinal plants known as Hua-Khao-Yen.
Tewtrakul S, Itharat A, Rattanasuwan P.
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand. [email protected]
Ethanolic- and water extracts from five species of Thai medicinal plants known as Hua-Khao-Yen were tested for their inhibitory effects against HIV-1 protease (HIV-PR) and HIV-1 integrase (HIV-1 IN). The result revealed that the ethanolic (EtOH) extract of Smilax corbularia exhibited anti-HIV-1 IN activity with an IC50 value of 1.9 microg/ml, followed by the water extract of Dioscorea birmanica (IC50 = 4.5 microg/ml), the EtOH extract of Dioscorea birmanica (IC50 = 4.7 microg/ml), the water extract of Smilax corbularia (IC50 = 5.4 microg/ml), the EtOH extract of Smilax glabra (IC50 = 6.7 microg/ml) and the water extract of Smilax glabra (IC50 = 8.5 microg/ml). The extracts of Pygmaeopremna herbacea and Dioscorea membranacea were apparently inactive (IC50 > 100 microg/ml). Interestingly, only the EtOH extract of Dioscorea membranacea showed appreciable activity (IC50 = 48 microg/ml) against HIV-1 PR, while the other extracts possessed mild activity. This result strongly supported the basis for the use of Smilax corbularia and Dioscorea membranacea for AIDS treatment by Thai traditional doctors.
Bioorg Med Chem. 2006 Mar 15;14(6):1710-4.
Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata.
Cheenpracha S, Karalai C, Ponglimanont C, Subhadhirasakul S, Tewtrakul S.
Department of Chemistry, Faculty of Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity. Structure-activity relationships of these compounds on anti-HIV-1 PR activity are summarized as follows: (1) hydroxyl moiety at position 4 conferred higher activity than methoxyl group; (2) prenylation of dihydrochalcone was essential for activity; (3) hydroxylation at position 4''' reduced activity; and (4) introduction of double bond at C1' and C6' of chalcone gave higher activity. As regards active constituents contained in B. pandurata rhizomes, hydroxypanduratin A (3) and panduratin A (2) are active principles against HIV-1 PR.
ความเห็น (1)
รบกวน Post รูปหัวข้าวเย็นด้วยได้ไหมคะ
เพื่อเป็นวิทยาทานคะ ขอบคุณคะ